• Low Extractable
• Excellent Biocompatibility
• Automatic Vent - Prevents air locking
• Hydrophilic Fibers - No surfactants used
• Tested and Approved Biocompatible
  • All materials pass U.S.P. XXI Class VI toxicity test
  • 100% integrity tested
  • Non-pyrogenic by LAL

The CultureGard™ hollow fiber filters are designed to reduce the risk of contamination to continuous perfusion cultures.

The use of two filters in series allows the user to easily change the first filter if it becomes contaminated or plugged. The second filter maintains the sterility of the culture. Luer connectors provide a convenient retrofit to any hollow fiber or deep tank bioreactor system. The first filter in the assembly removes contaminants in the media feed. Should removal of this filter become necessary due to contamination or plugging, the second filter continues to protect the downstream line and bioreactor from contamination. Filter life is dependent upon the type and quantity of the media being filtered. We recommend leaving the second filter on-line for the life of the culture or until flow is reduced to an unacceptable level.

All CultureGard™ units are manufactured with DynaFibre®, a 0,2 µm microporous naturally hydrophilic, hollow fiber membrane. The use of DynaFibre® results in low extractable and excellent biocompatibility. Each unit contains a unique autovent feature, which prevents air locking and allows for operation of the CultureGard™ assembly in any position. Manufactured to the highest standards CultureGard™ units are nonpyrogenic, noncytotoxic, 100% integrity tested and pass USP XXI Class VI toxicity testing.

CultureGard® filters are packaged non-sterile, in individual protective pouches, so they will need to be autoclaved before use. This system requires connecting two units in series. This allows you to change the first filter while the second filter remains in place to ensure sterility of the bioreactor system.

For details of autoclave cycle and replacement period please click here.

• CutureGard™ is intended for use with serum free media only. The present of serum in the media can greatly reduce the filtration capacity of CultureGard™ filters.
• Always use hose clamps to attach tubing to the CultureGard™ adaptors to prevent leakage.
• Aseptic conditions are required for the proper functioning of the product.
• Do not use operating temperatures in excess of 180° F (68° C) or operating pressures over 50 psi (3,5 bar) and do not exceed the recommended autoclave cycle of 30 minutes at 250° F (121° C)

• Housing/End Cap ....................................................Polysulfone
• Adaptors/Lock Nut ...............................................White Nylon
• Fiber...................................................Mixed Esters of Cellulose
• Vent Fiber...........................................................Polypropylene
• Inlet Connection .............................................Female Luer lock
• Outlet Connection ..............................................Male Luer lock
• Rated Pore Size..............................................................0.2 µm
• Continuous Operating pressure..............................30 psi (2 bar)
• Continuous Operating Temperature.....................113° F (45° C)